Clinical studies & documents

Acute phase proteins in healthy and sick cats

School of Veterinary Science, University of Queensland, Gatton, QLD 4343, Australia.
Research in Veterinary Science (Impact Factor: 1.77). 12/2011; 93(2):649-54. DOI: 10.1016/j.rvsc.2011.11.007
Source: PubMed

ABSTRACT Serum acute phase protein concentrations are used as diagnostic, therapeutic and prognostic markers in human and, less frequently, in animal medicine. The aim of this study was to determine how the health status and signalment of the cat are associated with concentrations of acute phase proteins. Generally, medians of the positive acute phase proteins appeared to be higher in sick cats compared to healthy cats. In multivariable regression models, log-transformed serum amyloid A concentration was higher in older cats, in sick and in female cats, while log-transformed α1-acid glycoprotein and haptoglobin concentrations were higher in older cats and were associated with interactions of health status (sick/healthy) and gender (male/female). The data from healthy cats in this study contribute to the limited knowledge of normal reference ranges for this species. This study highlights the potential of acute phase proteins as diagnostic markers in sick cats, but also emphasises that the signalment of the cat needs to be taken into consideration.

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Evaluation of in vitro diagnostic (point-of-care) system for quantification of the acute phase protein haptoglobin in cats

Jennifer Mattsson, Master's thesis in Biomedical Laboratory Science, Evidensia Animal Hospital, Malmö, Sweden
Spring 2014

This thesis consists of an evaluation of a new in vitro diagnostic point-of-care system for the quantification of the acute phase protein haptoglobin (Feline Haptoglobin, LifeAssays®). Acute phase proteins are biomarkers of systemic inflammation and can thus be used for diagnosis and monitoring of inflammation.1 ...
The results confirm that the method of analysis for Feline Haptoglobin evaluated can be used to identify cats with and without systemic inflammation.

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